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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-1
All Species:
18.18
Human Site:
S254
Identified Species:
40
UniProt:
P43699
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43699
NP_001073136.1
371
38596
S254
Q
Q
Q
A
Q
Q
Q
S
P
R
R
V
A
V
P
Chimpanzee
Pan troglodytes
XP_509911
401
41649
S284
Q
Q
Q
A
Q
Q
Q
S
P
R
R
V
A
V
P
Rhesus Macaque
Macaca mulatta
XP_001089890
371
38509
S254
Q
Q
Q
A
Q
Q
Q
S
P
R
R
V
A
V
P
Dog
Lupus familis
XP_849082
233
24205
L138
Q
L
Q
Q
D
G
G
L
G
P
P
P
P
P
P
Cat
Felis silvestris
Mouse
Mus musculus
P50220
372
38552
S255
Q
Q
Q
A
Q
Q
Q
S
P
R
R
V
A
V
P
Rat
Rattus norvegicus
P23441
372
38536
S255
Q
Q
Q
A
Q
Q
Q
S
P
R
R
V
A
V
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
L199
R
R
I
A
V
P
V
L
V
R
D
G
K
P
C
Frog
Xenopus laevis
P42587
196
22791
H101
L
S
A
P
E
R
E
H
L
A
S
L
I
R
L
Zebra Danio
Brachydanio rerio
Q90481
269
30288
Q174
T
Q
V
K
I
W
F
Q
N
H
R
Y
K
M
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
K204
W
F
Q
N
H
R
Y
K
C
K
R
Q
E
K
E
Sea Urchin
Strong. purpuratus
NP_999800
411
44821
Q304
Q
Q
Q
P
Q
Q
Q
Q
Q
Q
G
N
V
T
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.7
99.1
40.7
N.A.
98.1
98.6
N.A.
N.A.
32
30.7
32.6
N.A.
N.A.
N.A.
26.6
38.4
Protein Similarity:
100
91.7
99.1
46.6
N.A.
98.1
98.6
N.A.
N.A.
43.4
40.4
43.4
N.A.
N.A.
N.A.
40.4
50.3
P-Site Identity:
100
100
100
20
N.A.
100
100
N.A.
N.A.
13.3
0
13.3
N.A.
N.A.
N.A.
13.3
40
P-Site Similarity:
100
100
100
20
N.A.
100
100
N.A.
N.A.
26.6
26.6
20
N.A.
N.A.
N.A.
26.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
55
0
0
0
0
0
10
0
0
46
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
10
% C
% Asp:
0
0
0
0
10
0
0
0
0
0
10
0
0
0
0
% D
% Glu:
0
0
0
0
10
0
10
0
0
0
0
0
10
0
10
% E
% Phe:
0
10
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
10
0
10
0
10
10
0
0
0
% G
% His:
0
0
0
0
10
0
0
10
0
10
0
0
0
0
0
% H
% Ile:
0
0
10
0
10
0
0
0
0
0
0
0
10
0
0
% I
% Lys:
0
0
0
10
0
0
0
10
0
10
0
0
19
10
10
% K
% Leu:
10
10
0
0
0
0
0
19
10
0
0
10
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
0
0
0
10
0
0
0
0
10
0
0
10
0
0
0
% N
% Pro:
0
0
0
19
0
10
0
0
46
10
10
10
10
19
55
% P
% Gln:
64
64
73
10
55
55
55
19
10
10
0
10
0
0
10
% Q
% Arg:
10
10
0
0
0
19
0
0
0
55
64
0
0
10
0
% R
% Ser:
0
10
0
0
0
0
0
46
0
0
10
0
0
0
0
% S
% Thr:
10
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% T
% Val:
0
0
10
0
10
0
10
0
10
0
0
46
10
46
0
% V
% Trp:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _